Designing and optimization of liposomal nano-carriers containing Nepeta persica extract and study of its cytotoxicity on the breast cancer cell line (MCF-7)

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Designing and optimization of liposomal nano-carriers containing Nepeta persica extract and study of its cytotoxicity on the breast cancer cell line (MCF-7)

Introduction: Studies have shown that plant compounds have significant anticancer effects that if the challenges of using them are resolved, Can be the successor to the synthetic compounds commonly used in cancer therapy. Therefore, in this study, the liposomal nano- carriers containing Nepeta persica extract have been investigated in order to improve the physicochemical characteristics and eva...

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Designing and Characterizing Nano-carriers Containing Nepeta Persica Extract and Their Effect on Bone Cancer

Aims Niosomes have been considered as carriers for targeted delivery of drugs in modern drug delivery systems. The Iranian Nepta (Nepta genus) has unique biological properties; thus, this plant was used in this study to prepare the optimized formulation of niosomes containing extract, and to evaluate its cytotoxicity. Methods & Materials Initially, the extract of Iranian Nepta (N. persica) was...

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Introdution:The use of chemotherapy drugs has side effects and the use of herbal compounds in the treatment of cancer faces challenges. Nanoparticles, especially liposomes, with appropriate properties in drug delivery, such as slow drug release, low toxicity at the target cell site, can solve some of these problems. Therefore, the aim of the present study was to construct a liposomal system con...

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Cytotoxicity Effect of Cladribine on the MCF-7 Human Breast Cancer Cell Line

Cladribine, an analogue of deoxyadenosine, is highly toxic for both non-dividing and proliferating cells and has shown activity in the treatment of several malignancies. Therefore, the aim of the present study is to investigate the cytotoxicity effect of cladribine (2-CdA) on the breast cancer cell line, MCF-7 (estrogen receptor positive, ER+). MTT assay, annexin V-Fluorescein/PI and Hoechst 33...

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ژورنال

عنوان ژورنال: Journal of Shahid Sadoughi University of Medical Sciences

سال: 2019

ISSN: 2228-5733,2228-5741

DOI: 10.18502/ssu.v27i2.1041